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1.
Chinese Journal of Burns ; (6): 251-255, 2022.
Article in Chinese | WPRIM | ID: wpr-936002

ABSTRACT

Objective: To investigate the clinical effects of in situ perforation of preserved split scar matrix in combination with scalp transplantation and vacuum sealing drainage in the treatment of hypertrophic scar in non-functional sites after burns. Methods: A retrospective observational study was used. From June 2017 to June 2019, 33 patients (24 males and 9 females, aged 8-50 years) who met the inclusion criteria with hypertrophic scars in non-functional sites outside the face after burns were treated in General Hospital of TISCO (the Sixth Hospital of Shanxi Medical University). All patients underwent scalp transplantation after perforation of retained split scar matrix in situ (with scar thinning area of 90-500 cm2), and then the vacuum sealing drainage was performed. The hematoma and infection of wounds were observed on the 7th day after operation. At the same time, the survival rate of skin grafting was observed and calculated. The flatness and thickness of the scar in the operative area were observed in 12 months after operation, and the itching and pain of the patients were recorded. Vancouver Scar Scale was used to score the scar of patients before operation and at 3, 6 and 12 months after operation. The healing time and hair growth of donor site were observed. Data were statistically analyzed with repeated analysis of variance, paired sample t test and bonferroni correction. Results: On the 7th day after operation, local subcutaneous hematoma appeared in the wound of 2 patients, which healed after dressing change; no infection occurred. On the 7th day after operation, the survival rate of skin grafting of patients was 94.6%-99.0%(96.8±1.2)%. Scar flatness was well, the thickness of scar was not significantly higher than that of normal skin in 12 months after operation, and the symptoms of itching pain of patients disappeared or significantly relieved. Vancouver Scar Scale scores of patients before operation and at 3, 6, and 12 months after operation were 12.1±2.8, 8.5±1.5, 7.6±1.6, 6.7±1.3, respectively, and the scores of 3, 6, and 12 months after operation were all significantly lower than that before operation (with t values of 4.48, 4.06, and 3.97, respectively, P<0.01). All the donor sites of the head healed well in 4-7 days after operation. By 3-6 months after operation, all patients had good hair growth in the donor site and achieved no scar healing. Conclusions: The treatment of hypertrophic scar in non-functional sites outside the face after burns by in situ perforation of preserved split scar matrix in combination with scalp transplantation and vacuum sealing drainage can effectively improve the appearance of hypertrophic scar in non-functional areas after burn and reduce its degree of hyperplasia, with scar-free donor site healing.


Subject(s)
Adolescent , Adult , Child , Female , Humans , Male , Middle Aged , Young Adult , Burns/surgery , Cicatrix, Hypertrophic/surgery , Negative-Pressure Wound Therapy , Scalp/surgery , Skin Transplantation
2.
Rev. bras. cir. plást ; 34(4): 452-457, oct.-dec. 2019. ilus, tab
Article in English, Portuguese | LILACS | ID: biblio-1047899

ABSTRACT

Introdução: Abdominoplastia é um procedimento não apenas com características estéticas, mas também de reconstrução estrutural da parede abdominal. O objetivo do trabalho é mostrar a experiência dos autores em abdominoplastias, enfocando nos resultados estéticos da cicatriz e a evolução destes pacientes, aplicando as técnicas de ressecção em bloco do Professor Ronaldo Pontes (RP). Métodos: O estudo foi uma série retrospectiva de casos de 124 pacientes, entre março de 2014 a março de 2017, submetidos à abdominoplastia em bloco pela técnica RP. Resultados: Na nossa casuística, demonstrou-se uma mínima incidência de complicações encontradas com a técnica em Bloco RP, em comparação às encontradas na literatura, e, também, demonstrou um número pífio de casos de alterações na cicatrização. Conclusão: A técnica descrita e suas variantes atendem a necessidade de diversos tipos de casos e garantem cirurgias seguras e eficazes, com resultados muito satisfatórios, sendo uma técnica reprodutível.


Introduction: Abdominoplasty involves not only aesthetic characteristics but abdominal wall structural reconstruction. This study aimed to illustrate the authors' experience with abdominoplasty, focusing on the scar's aesthetic results and the evolution of application of the block resection technique of Professor Ronaldo Pontes (RP). Methods: The study included a series of retrospective cases of 124 patients treated between March 2014 and March 2017 who underwent RP block abdominoplasty. Results: In our studies, a minimal incidence of complications and a small number of healing alterations were noted with the RP block technique compared to those found in the literature. Conclusion: A técnica descrita e suas variantes atendem a necessidade de diversos tipos de casos e garantem cirurgias seguras e eficazes, com resultados muito satisfatórios, sendo uma técnica reprodutível.


Subject(s)
Humans , Male , Female , Adult , Middle Aged , History, 21st Century , Postoperative Complications , Cicatrix, Hypertrophic , Seroma , Esthetics , Abdominoplasty , Hematoma , Postoperative Complications/surgery , Cicatrix, Hypertrophic/surgery , Cicatrix, Hypertrophic/complications , Seroma/surgery , Abdominoplasty/adverse effects , Abdominoplasty/methods , Hematoma/surgery
3.
Rev. bras. cir. plást ; 32(4): 534-540, out.-dez. 2017. ilus, tab
Article in English, Portuguese | LILACS | ID: biblio-878773

ABSTRACT

Introdução: O abdome é um segmento estético-funcional importante na caracterização do contorno corporal. Na abdominoplastia, o posicionamento e o formato da cicatriz umbilical são importantes para um resultado satisfatório. Este estudo teve como objetivo descrever a técnica de onfaloplastia vertical, bem como apresentar os resultados obtidos. Métodos: Estudo longitudinal retrospectivo descritivo composto por pacientes submetidos à onfaloplastia vertical durante a abdominoplastia clássica no período de 2014 a 2017. A técnica consistiu em uma incisão linear vertical transcutânea sem retirada de fuso de pele e com mínimo desengorduramento da parede ao redor do umbigo, seguida da confecção de um ponto na porção lateral do pedículo umbilical, transfixante, permitindo sua invaginação e fixação rente à aponeurose do reto abdominal. Resultados: Do total de 128 pacientes avaliados, a faixa etária variou de 25 a 62 anos, com média de 32 anos. O tempo médio do ato operatório foi de 2 horas e 33 minutos. Não foram observadas complicações cirúrgicas como hematoma ou necrose do retalho abdominal. Foram observados 2 casos de deiscências, 4 casos de cicatriz hipertrófica, com 2 evoluindo para estenose umbilical e 1 caso de necrose umbilical. No seguimento ambulatorial 92,2% dos pacientes mostraram-se muito satisfeitos com o resultado final obtido. A análise técnica apresentou um grau de satisfação de 88,8% dos casos. Conclusão: A técnica descrita apresenta resultados satisfatórios, diminui a possibilidade do surgimento do anel cicatricial e permite minimizar um dos estigmas da abdominoplastia, que é uma cicatriz umbilical muito visível.


Introduction: The abdomen is an important aesthetic functional segment in the characterization of the body contour. In abdominoplasty, the placement and shape of the umbilical scar are important for a satisfactory result. This study aimed to describe the technique of vertical omphaloplasty and to present the results obtained. Methods: Retrospective longitudinal descriptive study composed of patients who underwent vertical omphaloplasty during classic abdominoplasty between 2014 and 2017. The technique consists of a vertical transcutaneous incision without removal of the skin spindle and with minimal degreasing of the wall around the umbilicus, followed by the transfixing a point in the lateral portion of the umbilical pedicle, allowing its invagination and fixation close to the aponeurosis of the rectus abdominis. Results: In the 128 patients evaluated, the patients' age ranged from 25 to 62 years, with a mean of 32 years. The mean time of surgery was 2 h and 33 min. No surgical complications occurred, such as hematoma or abdominal flap necrosis. Two cases of dehiscence, four cases of hypertrophic scar, two cases of stenosis, and one case of umbilical necrosis were observed. In outpatient follow-up, 92.2% of the patients were very satisfied with the final result. The technical analysis presented an 88% degree of satisfaction. Conclusion: The technique described presents satisfactory results, reduces the possibility of the appearance of a cicatricial ring, and allows minimizing one of the stigmas of abdominoplasty, which is a very visible umbilical scar.


Subject(s)
Humans , Male , Female , Adult , Middle Aged , History, 21st Century , Surgical Procedures, Operative , Umbilicus , Retrospective Studies , Patient Satisfaction , Cicatrix, Hypertrophic , Abdomen , Abdominoplasty , Surgical Procedures, Operative/methods , Umbilicus/surgery , Cicatrix, Hypertrophic/surgery , Cicatrix, Hypertrophic/therapy , Abdominoplasty/methods , Abdomen/surgery
4.
An. bras. dermatol ; 92(4): 474-477, July-Aug. 2017. tab, graf
Article in English | LILACS | ID: biblio-887001

ABSTRACT

Abstract: Background: Surgical sutures, wound tension, additional skin incisions and other factors may result in recurrence of tumor-like scar. Objective: To investigate the role of wound natural healing therapy in tumor-like hypertrophic scar. Methods: In this study, tumor-like hypertrophic scars of 47 cases were excised completely and the residual wounds were treated with natural healing. The short-term and long-term effects of treatment were evaluated. Results: All cases were successfully cured by natural healing therapy. The healing time of the maximum wound (80mm × 20mm) and the minimal wound (5mm× 5mm) was 25 days and 7 days respectively. The size of new skin scars ranged from 3mm to 11 mm. Clinical followed-up was performed in 34 cases for 36 months. Among them, no recurrence happened in 31 cases and new scar size ranged from 2mm to 8mm, while local recurrence happened in 3 cases whose scar size were less than 5 mm. Study Limitations: The cure rate of the therapy was 91.2%. Conclusion: The wound natural healing therapy is effective in treating tumor-like hypertrophic scar, which can prevent recurrence and has good cosmetic results.


Subject(s)
Male , Female , Child , Adolescent , Adult , Middle Aged , Aged , Young Adult , Wound Healing/physiology , Cicatrix, Hypertrophic/surgery , Wound Closure Techniques , Postoperative Period , Recurrence , Surgical Wound Infection/etiology , Sutures/adverse effects , Suture Techniques/adverse effects , Treatment Outcome , Cicatrix, Hypertrophic/pathology , Cicatrix, Hypertrophic/prevention & control , Preoperative Period
5.
Rev. Assoc. Med. Bras. (1992) ; 62(9): 862-866, Dec. 2016. tab, graf
Article in English | LILACS | ID: biblio-829553

ABSTRACT

SUMMARY Introduction Since the 1980s, the use of autologous fat grafting has been growing in plastic surgery. Recently, this procedure has come to be used as a treatment for keloids and hypertrophic scars mainly due to the lack of satisfactory results with other techniques. So far, however, it lacks more consistent scientific evidence to recommend its use. The aim of this study was to review the current state of autologous fat grafting for the treatment of keloids and hypertrophic scars, their benefits and scientific evidences in the literature. Method A review in the Pubmed database was performed using the keywords “fat grafting and scar”, “fat grafting and keloid scar” and “fat grafting and hypertrophic scar.” Inclusion criteria were articles written in English and published in the last 10 years, resulting in 15 studies. Results These articles indicate that autologous fat grafting carried out at sites with pathological scars leads to a reduction of the fibrosis and pain, an increased range of movement in areas of scar contraction, an increase in their flexibility, resulting in a better quality of scars. Conclusion So far, evidences suggest that autologous fat grafting for the treatment of keloids and hypertrophic scars is associated with a better quality of scars, leading to esthetic and functional benefits. However, this review has limitations and these findings should be treated with reservations, since they mostly came from studies with low levels of evidence.


RESUMO Introdução a partir da década de 1980, o uso da lipoenxertia autóloga tem crescido na cirurgia plástica. Recentemente, esse procedimento passou a ser utilizado como tratamento de queloides e cicatrizes hipertróficas, principalmente em decorrência da falta de resultados satisfatórios com outras técnicas. No entanto, até o momento, faltam evidências científicas mais consistentes que recomendem seu uso. O objetivo deste estudo foi realizar uma revisão do estado atual da lipoenxertia autóloga no tratamento de queloides e cicatrizes hipertróficas, os benefícios e as evidências científicas presentes na literatura. Método foi realizada uma revisão na base de dados Pubmed com os descritores “fat grafting and scar”, “fat grafting and keloid scar” e “fat grafting and hypertrofic scar”. Os critérios de inclusão foram artigos escritos em inglês e publicados nos últimos 10 anos, resultando em 15 estudos. Resultados os artigos indicam que a lipoenxertia autóloga realizada em locais com cicatrizes patológicas leva a uma diminuição da fibrose e da dor, à maior amplitude de movimentos em áreas de retração cicatricial, ao aumento de sua maleabilidade, resultando na melhor qualidade das cicatrizes. Conclusão até o momento, as evidências sugerem que a lipoenxertia autóloga para o tratamento das queloides e cicatrizes hipertróficas está associada à uma melhor qualidade das cicatrizes, levando a benefícios estéticos e funcionais. Contudo, esta revisão possui limitações e os acha dos devem ser analisados com ressalvas, já que a maioria provem de estudos com baixos níveis de evidência.


Subject(s)
Humans , Adipose Tissue/transplantation , Cicatrix, Hypertrophic/surgery , Keloid/surgery , Pain, Postoperative/therapy , Treatment Outcome , Cicatrix, Hypertrophic/metabolism , Keloid/metabolism
6.
Rev. bras. cir. plást ; 30(4): 638-648, sep.-dec. 2015. ilus, tab
Article in English, Portuguese | LILACS | ID: biblio-1417

ABSTRACT

Introdução: Considerando um número estimado de cerca de 51 milhões de cirurgias a cada ano apenas nos EUA, podemos dizer que a hipertrofia cicatricial é um problema relevante, já que uma cicatriz fina, de boa qualidade, pode ser a linha divisória entre um bom resultado e uma cirurgia malsucedida. O objetivo é fazer uma revisão bibliográfica acerca dos métodos de tratamento não invasivos atualmente disponíveis para a prevenção da hipertrofia cicatricial pós-cirúrgica e discutir a sua eficácia baseada em evidências. Método: Foi realizada uma pesquisa nas bases de dados Pubmed, Lilacs e SciELO, utilizando os termos "scar prevention" and "hypertrophic scars", por ensaios clínicos, meta-análises e artigos de revisão publicados a partir de 2004, em inglês ou português. Resultados e Conclusões: Foram encontrados vários trabalhos utilizando o silicone, proporcionando alguma evidência acerca da sua eficácia; foram encontrados apenas três ensaios clínicos prospectivos relacionados ao uso do Contractubex®; dois ensaios clínicos prospectivos, controlados, randomizados, sendo apenas um deles duplo-cego, com o imiquimode a 5%; foi encontrado apenas um ensaio clínico bem desenhado utilizando o esparadrapo microporoso e outro trabalho relacionado ao uso da vitamina E, que não mostrou bons resultados; não foram encontrados ensaios clínicos sobre o uso da massagem e da pressão local. Apesar das deficiências dos estudos, o silicone é considerado a primeira opção na prevenção da hipertrofia cicatricial pós-cirúrgica. Não há evidências que comprovem a eficácia do esparadrapo microporoso, da massagem, da pressão local, do Contractubex, do imiquimode a 5% e da vitamina E.


Introduction: Considering that nearly 51 million surgeries are performed annually just in the USA, we can state that scar hypertrophy is a relevant problem, since a thin, good quality scar can be the dividing line between a good outcome and an unsuccessful surgery. The objective is to perform a bibliographic review of the noninvasive methods currently available to prevent postoperative hypertrophic scars and discuss their evidence-based effectiveness. Method: A search was performed in PubMed, LILACS, and SciELO databases, using the terms "scar prevention" and "hypertrophic scars," for clinical trials, meta-analyses, and review articles published since 2004 in English or Portuguese language. Results and Conclusions: Several studies using silicone were found, providing some evidence on its effectiveness; only 3 prospective clinical trials using Contractubex® were found; 2 controlled, randomized prospective clinical trials using 5% imiquimod were found, but only one was doubleblind; one well-designed clinical trial using a micropore adhesive tape was found; a similar clinical trial using vitamin E did not show good results. Clinical trials on the use of massage and local pressure were not found. Despite the limitations of the studies, silicone is considered the first treatment option for the prevention of postoperative hypertrophic scars. There is no evidence proving the effectiveness of micropore adhesive tape, massage, local pressure, Contractubex, 5% imiquimod, or vitamin E.


Subject(s)
Humans , History, 21st Century , Postoperative Complications , Silicones , Vitamin E , Wounds and Injuries , Review Literature as Topic , Prospective Studies , Cicatrix, Hypertrophic , Clinical Study , Hypertrophy , Postoperative Complications/surgery , Silicones/therapeutic use , Vitamin E/therapeutic use , Vitamin E/pharmacology , Wounds and Injuries/surgery , Wounds and Injuries/therapy , Cicatrix, Hypertrophic/surgery , Cicatrix, Hypertrophic/prevention & control , Hypertrophy/surgery , Hypertrophy/therapy
7.
Rev. bras. cir. plást ; 30(4): 515-521, sep.-dec. 2015. ilus
Article in English, Portuguese | LILACS | ID: biblio-1363

ABSTRACT

INTRODUÇÃO: A obesidade é considerada pela Organização Mundial de Saúde (OMS) a principal pandemia do século. A obesidade mórbida tem como um de seus tratamentos mais efetivos a cirurgia bariátrica, e muitos pacientes necessitarão de cirurgia plástica reparadora após grandes emagrecimentos. Dentre as cirurgias em ex-obesos, a mais associada a complicações é a dermolipectomia. O propósito deste estudo foi mostrar a experiência do autor na dermolipectomia em âncora após grande emagrecimento, enfocando as complicações e a satisfação do paciente. MÉTODOS: Revisamos 40 prontuários de pacientes operados entre setembro de 2011 e abril de 2013, cinco deles não foram localizados e, por isso, excluídos do estudo. Foi solicitado que pontuassem de 1 a 4, sendo 1 (insatisfeito), 2 (pouco satisfeito), 3 (satisfeito), 4 (muito satisfeito). Consideramos as complicações trans e pós-operatórias, tempo cirúrgico, permanência hospitalar, tempo com dreno, idade e gênero. Foi realizada análise estatística dos dados, assim como estatística descritiva. RESULTADOS: Nosso estudo avaliou 35 pacientes, apenas um era homem (2,85%), a idade variou de 27 a 68 anos (média 41,25 anos), o peso pré-operatório variou de 58 a 108 kg (média de 73,6 kg), 94,28% dos pacientes sentiam-se satisfeitos (pontuação 3 e 4). A principal complicação foi o seroma 28,5%, seguida pela cicatriz hipertrófica (17,14%), nenhuma complicação maior foi verificada. O tempo médio do procedimento cirúrgico foi de 103 minutos (75-140 minutos). Alta ocorreu com 24h de internação hospitalar. CONCLUSÃO: A dermolipectomia em âncora é um método seguro e efetivo para o contorno corporal do ex-obeso.


INTRODUCTION: Obesity is designated by the World Health Organization (WHO) as the major pandemic of this century. Bariatric surgery is one of the most effective treatments of morbid obesity, since most patients are submitted to reconstructive plastic surgery after major weight loss. Among the surgeries carried out in the formerly obese, dermolipectomy is the procedure that is mostly associated with complications after surgery. The aim of this study was to report the experience of the author in performing anchor dermolipectomy after major weight loss, focusing on complications and patient satisfaction rate. METHODS: The medical records of 40 patients operated between September 2011 and April 2013 were reviewed in the study. Five patients were excluded from the study, since they could not be found. The patients were asked to score their satisfaction from 1 to 4, where 1 means dissatisfied, 2 poorly satisfied, 3 satisfied, and 4 very satisfied. Trans and post-operative complications, surgical time, hospital stay, drainage time, age, and gender were considered in the study. The data obtained were submitted to a statistical analysis and descriptive statistics. RESULTS: Among the 35 patients evaluated in our study, only one was male (2.85%). The age varied between 27 and 68 years (average age of 41.25 years). The preoperative weight varied from 58 to 108 kg (average of 73.6 kg); 94.28% of the patients declared themselves as satisfied (score 3 and 4). The main complication was the occurrence of seroma (28.5%), followed by hypertrophic scar (17.14%). No major complication was observed. The average surgical time was 103 minutes (75-140 minutes). The patient was discharged 24 hours after hospital admission. CONCLUSION: Anchor dermolipectomy is a safe and effective body contouring procedure to be carried out in the formerly obese.


Subject(s)
Humans , Female , Adult , Middle Aged , Aged , History, 21st Century , Postoperative Complications , Surgical Procedures, Operative , Obesity, Morbid , Weight Loss , Medical Records , Data Interpretation, Statistical , Patient Satisfaction , Cicatrix, Hypertrophic , Evaluation Study , Seroma , Bariatric Surgery , Obesity , Postoperative Complications/surgery , Surgical Procedures, Operative/methods , Obesity, Morbid/surgery , Obesity, Morbid/complications , Medical Records/standards , Patient Satisfaction/statistics & numerical data , Cicatrix, Hypertrophic/surgery , Cicatrix, Hypertrophic/complications , Seroma/surgery , Seroma/complications , Bariatric Surgery/adverse effects , Bariatric Surgery/methods , Bariatric Surgery/statistics & numerical data
9.
Rev. bras. cir. plást ; 27(2): 185-189, abr.-jun. 2012. ilus, tab
Article in Portuguese | LILACS | ID: lil-648484

ABSTRACT

INTRODUÇÃO: Queloide e cicatriz hipertrófica são cicatrizes patológicas com natureza fisiopatogênica comum, denominadas, em conjunto, cicatrizes fibroproliferativas. São mais frequentes em indivíduos de pele mais escura. Contudo, a atual miscigenação dificulta o enquadramento dos pacientes com variadas tonalidades de pele em classificações morfológicas e estáticas (branco ou caucasoide, mulato, pardo, hispânico ou latino, amarelo ou oriental ou mongoloide e negro ou negroide), e diferentes quanto à exposição solar. Sabe-se que pessoas oriundas de países de clima temperado ou frio quando residem em países tropicais aumentam a incidência dessas cicatrizes, principalmente nas áreas de maior exposição solar. Uma relação entre as cicatrizes fibroproliferativas e os fototipos de Fitzpatrick, classificação dinâmica baseada no relato do paciente quanto a sua resposta cutânea após a exposição solar, poderia contribuir para a compreensão da fisiopatologia dessas cicatrizes. Este estudo teve como objetivo investigar a distribuição das cicatrizes fibroproliferativas segundo os fototipos de Fitzpatrick. MÉTODO: Foram avaliados 146 pacientes provenientes do Ambulatório da Disciplina de Cirurgia Plástica da Universidade Federal de São Paulo (Unifesp, São Paulo, SP, Brasil), portadores de qualquer tipo de cicatriz fibroproliferativa, em um ou mais locais do corpo. As cicatrizes fibroproliferativas dos pacientes foram classificadas de acordo com os critérios de Muir em cicatriz tipo queloide (Long-term Evolution, LTE), cicatriz tipo hipertrófica (Short-term Evolution, STE) e cicatriz tipo mista (Intermediate Group, IG), e os tipos de pele foram classificados segundo os fototipos de Fitzpatrick. RESULTADOS: O fototipo Fitzpatrick III e a cicatriz mista foram mais frequentes entre os pacientes avaliados (P = 0,001). Houve associação (P = 0,025) entre as cicatrizes fibroproliferativas e os fototipos de Fitzpatrick, ou seja, quanto maior o fototipo maior a tendência de desenvolvimento de cicatrizes dos tipos queloide e mista. CONCLUSÕES: Os fototipos de pele segundo Fitzpatrick mostraram-se válidos como critério a ser utilizado em estudos de queloide e cicatriz hipertrófica.


BACKGROUND: Keloid and hypertrophic scars have a common physiopathogenic origin and are defined as fibroproliferative scars. Fibroproliferative scars are frequent in individuals with darker skin. However, mixing of "races" renders it difficult to group patients with different skin tones according to morphological and static classifications (white for Caucasians; brown for individuals of Spanish descent (Hispanic/Latino); yellow for individuals of East Asian descent; and black for individuals of African descent) according to their response to sun exposure. It is known that when individuals whose ethnic origin is in colder countries move to tropical countries, they show a higher incidence of these types of scars, which mainly affect parts of the body that are more exposed to the sun. A correlation between fibroproliferative scars and Fitzpatrick phototype, a dynamic classification based on the skin's response to sun exposure, would contribute to an understanding of the pathophysiology of these scars. The aim of this study is to investigate the distribution of fibroproliferative scars according to Fitzpatrick phototypes. METHODS: We classified patients' fibroproliferative scars according to the Muir classification as Long-Term Evolution (keloid scars), Short-Term Evolution (hypertrophic scars), and Intermediate Group (mixed scars), while their skin types were grouped according to the Fitzpatrick classification. RESULTS: Fitzpatrick phototype III and mixed scars were predominant among the patients analyzed (p = 0.001). A correlation (p = 0.025) was observed between fibroproliferative scars and Fitzpatrick phototypes; the higher the phototype, the higher the tendency to develop keloid and mixed scar tissue. CONCLUSIONS: Fitzpatrick skin phototypes proved to be an efficient method to study keloid and hypertrophic scars.


Subject(s)
Humans , Male , Female , Young Adult , Middle Aged , Cicatrix, Hypertrophic/surgery , Cicatrix/physiopathology , Ethnicity , Melanocytes , Keloid/surgery , Ultraviolet Rays , Skin Pigmentation , Diagnostic Techniques and Procedures , Methods , Patients
10.
Rev. bras. cir. plást ; 25(2): 372-378, abr.-jun. 2010. ilus
Article in Portuguese | LILACS | ID: lil-579345

ABSTRACT

Introdução: Existe pouco entendimento a respeito dos mecanismos que levam à formação dos quelóides e cicatrizes hipertróficas (CHT), assim como não há um tratamento padrão-ouro para essas lesões. Experiências recentes demonstraram que as alterações na formação dessas cicatrizes envolvem concentrações desequilibradas de fatores de crescimento locais, em particular o fator de crescimento transformador (TGF) β1. O tamoxifeno, ao inibir a produção desta citocina, pode ser uma nova opção na conduta terapêutica destas lesões. Método: Dezoito pacientes portadores de quelóides e CHT foram selecionados para a avaliação do uso do citrato de tamoxifeno 0,1% por um período de seis meses. Durante essa evolução, foi realizado registro fotográfico, mensuração e análise histopatológica das lesões e questionários relativos a aspectos da lesão foram aplicados aos pacientes. Resultados: Houve redução significativa da altura(p < 0,0001), da largura (p = 0,009) e do comprimento (p = 0,009) das lesões. Os critérios de textura, altura e prurido foram os que obtiveram as maiores variações entre os períodos pré e pós-tratamento. As alterações histológicas sugerem uma ação de remodelamento do colágeno nessas cicatrizes. Conclusões: O citrato de tamoxifeno apresentou uma resposta favorável na maioria dos critérios analisados, mínimos efeitos colaterais e baixo custo, constituindo uma opção de tratamento segura e cômoda, principalmente nas CHT. São necessários novos estudos com maior amostragem para obtenção de conclusões mais abrangentes.


Background: Keloids and hypertrophic scars (HScs) are poorly understood cicatricial lesions without a gold-standard treatment. Recent experiments demonstrated that cytokines imbalance has an action in scar pathogenesis, mainly due to transforming growth factor (TGF) β1 over expression. Tamoxifen, an antioestrogenic drug, can inhibit TGF-β1 release and consequently fibroblastic proliferation. This indicates a possible role of Tamoxifen as a therapeutic option in keloids and HScs. Method: Eighteen patients were selected for the evaluation of tamoxifen citrate 0.1% for six months. During that evolution, photographic registration, dimensional evaluation and hystopathologic analisis of the lesions were accomplished and questionnaires about aspects of the lesion were applied to patients. Results: There was a significant reduction of the lesion height (p < 0.0001), width (p = 0.009) and length (p = 0.009). Texture criteria, height and itch were the ones that obtained the largest variations among the periods before and after treatment. Histological changes suggested remodelling action of the collagen in those scars. Conclusions: Tamoxifen citrate presented positive results in most of the analyzed criteria, minima side effects and low cost, constituting a safe and comfortable treatment option, mainlyin HScs. There will be necessary more research with larger sampling for greater conclusions.


Subject(s)
Humans , Male , Female , Adult , Cytokines , Cicatrix, Hypertrophic/surgery , Keloid/surgery , Surgical Procedures, Operative , Tamoxifen , Wounds and Injuries , Diagnostic Techniques and Procedures , Histological Techniques , Methods , Patients
11.
Rev. bras. cir. plást ; 24(3): 281-285, jul.-set. 2009. ilus, graf
Article in Portuguese | LILACS | ID: lil-535673

ABSTRACT

Introdução: O quelóide é uma alteração cicatricial de alta prevalência e difícil tratamento. Essa pesquisa é baseada em uma modalidade conjunta de efeito comprovado na literatura, a aplicação de corticosteróide intralesional associada à cirurgia. Algumas referências citam a importância da excisão intralesional do quelóide, baseando-se na experiência clínica dos cirurgiões. O objetivo desta pesquisa é avaliar se no tratamento do quelóide com corticosteróide intralesional mais excisão cirúrgica a manutenção ou não de tecido queloidiano nas bordas da ferida operatória influencia no índice de recidiva. Método: Estudo prospectivo que avaliou 42 pacientes em um total de 60 lesões queloidianas, no período de agosto de 2005 a janeiro de 2008, comparando três grupos cada qual com 20 lesões alocadas de forma aleatória. Foi realizada excisão intralesional no grupo 1; justalesional (sem margem macroscópica) no grupo 2 e extralesional (com margem de 2 mm) no grupo 3. O tratamento com corticosteróide intralesional foi realizado da mesma forma em todos os pacientes. A variável de desfecho foi clínica: índice de recidiva. Resultados: Após o acompanhamento de dois anos, a taxa de recidiva do quelóide foi de 20% no grupo 1, 45% no grupo 2 e 77,5% no grupo 3 (p=0,024). Conclusão: Quanto ao tratamento cirúrgico, justifica-se a excisão intralesional, mantendo as bordas do tecido queloidiano, por estar associada a menor índice de recidiva quando comparado à excisão justa ou extralesional.


Introduction: Keloid is a scar tissue abnormality of high prevalence and difficult treatment. This research is based on a scientific literature proved combined tactical, the intralesional corticosteroid injection associated with surgery. Some references cite the importance of intralesional excision of keloid, based upon clinical experience of a few surgeons. The objective is to assess the influence of maintaining or not keloid tissue in the surgical wound edges in the intralesional corticosteroid injection plus surgical excision method, in the recurrency of keloid. Methods: Prospective study with 42 patients in a total of 60 keloid lesions, from August 2005 to January 2008, comparing three groups, each one with 20 lesions randomly distributed. Intralesional excision was performed in group 1; with no macroscopic borders in group 2; and extralesional (2 mm borders) in group 3. The intralesional corticosteroid injection was performed the same way in all patients. The analyzed outcome was clinical: keloid recrudescency taxes. Results: After the two year follow-up, the keloid recrudescency taxes was about 20% in group 1, 45% in group 2 and 77.5% in group 3 (p=0.024). Conclusions: The intralesional excision is justified, for being associated with lower recrudescency taxes, when compared with excisions with none or 2 mm borders.


Subject(s)
Humans , Male , Female , Adolescent , Adult , Middle Aged , Cicatrix, Hypertrophic/surgery , Cicatrix/surgery , Adrenal Cortex Hormones/therapeutic use , Keloid/surgery , Wounds and Injuries , Methods , Recurrence , Diagnostic Techniques and Procedures
12.
New Egyptian Journal of Medicine [The]. 1998; 19 (Supp. 2): 29-32
in English | IMEMR | ID: emr-49101

ABSTRACT

Twenty one keloids and hypertrophied scars in sixteen patients were subjected to intralesional laser excision, followed immediately by application of silicone gel sheeting for three months and intralesional steroid injection which started two weeks postoperatively after complete wound healing and was done every other week for two months. Improvement in color, texture and thickness of the scars was noted. No failure or recurrence following this combined therapy was observed after six months


Subject(s)
Humans , Male , Female , Cicatrix, Hypertrophic/surgery , Laser Therapy , Prognosis , Adrenal Cortex Hormones , Treatment Outcome , Silicone Gels
13.
Acta méd. colomb ; 17(1): 31-45, ene.-feb. 1992. tab, graf
Article in Spanish | LILACS | ID: lil-183217

ABSTRACT

Wound healing is a natural response to injury. The process takes place in all body tissues. Its normal development in a given tissue, organ or system is of pivotal importance for surgery. This review describes the advances made during this century in regard to better knowledge and understanding of woud healing. Recent developments such a growth factors, electric techniques, and hyperbaricoxygen therapy are minutely descussed.


Subject(s)
Humans , Cicatrix/physiopathology , Cicatrix/surgery , Cicatrix, Hypertrophic/surgery , Cicatrix, Hypertrophic/physiopathology , Wound Healing , Wound Healing/physiology , Wound Healing/immunology
14.
Rev. colomb. cir ; 6(supl.2): 48-53, jul. 1991. ilus
Article in Spanish | LILACS | ID: lil-328718

ABSTRACT

Se analizan aspectos basicos de la fisiopatologia de la cicatrizacion y los tipos anómalos de la misma: hipertrofia y queloide. Se mencionan algunos factores etiológicos de la cicatrización patológica y se comentan diversos metodos terapeuticos, tales como la cirugia, la radioterapia, el uso de corticoides, la presion mantenida, la gelatina siliconada topica y el metodo combinado; simultaneamente se plantean los resultados obtenidos con cada uno de los metodos mencionados.


Subject(s)
Cicatrix, Hypertrophic/surgery , Cicatrix, Hypertrophic/complications , Cicatrix, Hypertrophic/therapy
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